While Bayer says it wants to ensure the drug gets into the hands of patients and doesn't sit in a distribution chain, the hemophilia community is angry that the limited supply of Kogenate FS will only be available to enrollees of Bayer Direct, and that patients could be “cherry-picked” based on the reimbursement generosity of their insurance plans (something Bayer denies). “We've moved forward as quickly as science would allow, and keeping safety and efficacy in mind,” says Doug Bell, Bayer's director of global public policy and communications Meanwhile, Bayer is awaiting FDA approval for a new, 200-liter fermenter (to replace one half the size) in its Berkeley, CA facility. Genetics Institute (Cambidge, MA), which received US marketing approval for its recombinant factor VIII product, Refacto, in March, has postponed product launch until 2001 due to production problems and high demand in Europe. It is also constructing a third production site.
Baxter (Deerfield, IL), which owns over half the market share, recently doubled the capacity of its Thousand Oaks, CA manufacturing facility, and is awaiting FDA clearance to ship product. For more information check out the documentation.Īs of January 1st 2017, ReShade is open sourced under the terms and conditions of the BSD 3-clause license! You can help development with your own contributions via the official GitHub repository.In addition, only three companies account for all recombinant factor VIII made in the US, and there have been delays in the construction and approval of new production facilities. ReShade 5.0 introduced a powerful add-on API that makes it possible to write add-ons for both ReShade and the games it is used with. Write your shaders just once, they'll work everywhere, regardless of your target being Direct3D or OpenGL: ReShade takes care of compiling them to the right shader model and language (HLSL, GLSL or SPIR-V).
The syntax is based on HLSL, adding useful features designed for developing post-processing effects: Define and use textures right from the shader code, render to them, change renderstates, retrieve color and depth data, request custom values like timers or key states. ReShade features its very own shading language and compiler, called ReShade FX. NET Framework 4.6.2 or higher installed is required. ReShade supports all of Direct3D 9, Direct3D 10, Direct3D 11, Direct3D 12, OpenGL and Vulkan.Ī computer with Windows 7 SP1, 8.1, 10 or 11 and.
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